A diet rich in high glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles through modulating mitochondrial function

submitted by: Andrew Chapple
Background: Observational and experimental studies suggest that diets rich in cruciferous vegetables and glucosinolates may reduce the risk of cancer and cardiovascular disease (CVD). Objective: We tested the hypothesis that a 12-wk dietary intervention with high-glucoraphanin (HG) broccoli would modify biomarkers of CVD risk and plasma metabolite profiles to a greater extent than interventions with standard broccoli or peas. Design: Subjects were randomly assigned to consume 400 g...
Authors: Charlotte Armah, Maria Traka, Jack Dainty, Marianne Defernez, Astrid Janssens, Wing Leung, John Potter, Richard Mithen

A Whole-Grain–Rich Diet Reduces Urinary Excretion of Markers of Protein Catabolism and Gut Microbiota Metabolism in Healthy Men after One Week

submitted by: Alastair Ross
Epidemiological studies consistently find that diets rich in whole-grain (WG) cereals lead to decreased risk of disease compared with refined grain (RG)-based diets. Aside from a greater amount of fiber and micronutrients, possible mechanisms for why WGs may be beneficial for health remain speculative. In an exploratory, randomized, researcherblinded, crossover trial, we measured metabolic profile differences between healthy participants eating a diet based on WGs compared with a diet...
Authors: Alastair Ross, Emma Pere-Trépat, Ivan Montoliu, Francois-Pierre Martin, Sebastiano Collino, Sofia Moco, Jean-Philippe Godin, Marilyn Cléroux, Philippe Guy, Isabelle Breton, Rodrigo Bibiloni, Anita Thorimbert, Isabelle Tavazzi, Lionel Tornier, Aude Bebuis, Stephen Bruce, Maurice Beaumont, Laurent-Bernard Fay, Sunil Kochhar

Metabolomics and the Microbiome (MWV45)

submitted by: MicrobeWorld
In episode 45 of MicrobeWorld Video, filmed at the American Association for the Advancement of Science Meeting in Washington, D.C., Dr. Stan Maloy talks with Jeremy Nicholson, Head of the Department of Surgery & Cancer at Imperial College London, about his work with metabolomics and the human gut. Maloy and Nicholson discuss the science of metabolomics, the systematic study of the unique chemical fingerprints that specific cellular processes leave behind, and how gut microbial...