BMI and all-cause mortality in older adults: a meta-analysis

submitted by: winterj
Background: Whether the association between body mass index (BMI) and all-cause mortality for older adults is the same as for younger adults is unclear. Objective: The objective was to determine the association between BMI and all-cause mortality risk in adults ?65 y of age. Design: A 2 stage random-effects meta-analysis was performed of studies published from 1990 to 2013 that reported the RRs of all-cause mortality for community-based adults aged ?65 y. Results: Thirty-two studies met...
Authors: Jane Winter, Robert MacInnis, Naiyana Wattanapenpaiboon, Caryl Nowson

Belief beyond the evidence: using the presumed effect of breakfast on obesity

submitted by: awbrown
Background: Various intentional and unintentional factors in?uence beliefs beyond what scienti?c evidence justi?es. Two such factors are research lacking probative value (RLPV) and biased research reporting (BRR). Objective: We investigated the prevalence of RLPV and BRR in research about the proposition that skipping breakfast causes weight gain, which is called the proposed effect of breakfast on obesity (PEBO) in this article. Design: Studies related to the PEBO were synthesized...
Authors: David Allison, Michelle Bohan Brown, Andrew Brown

Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis

submitted by: vmalik
Background: The relation between sugar-sweetened beverages (SSBs) and body weight remains controversial. Objective: We conducted a systematic review and meta-analysis to summarize the evidence in children and adults. Design: We searched PubMed, EMBASE, and Cochrane databases through March 2013 for prospective cohort studies and randomized controlled trials (RCTs) that evaluated the SSB-weight relation. Separate meta-analyses were conducted in children and adults and for cohorts and...
Authors: Vasanti Malik, An Pan, Walter Willett, Frank Hu

Is there a dose-response relation of dietary glycemic load to risk of type 2 diabetes? Meta-analysis of prospective cohort studies

submitted by: Geoffrey Livesey
Background: Although much is known about the association between dietary glycemic load (GL) and type 2 diabetes (T2D), prospective cohort studies have not consistently shown a positive dose-response relation. Objective: We performed a comprehensive examination of evidence on the dose response that links GL to T2D and sources of heterogeneity among all prospective cohort studies on healthy adults available in the literature. Design: We conducted a systematic review of all prospective...
Authors: Geoffrey Livesey, Richard Taylor, Helen Livesey, Simin Liu

Multivitamin-multimineral supplementation and mortality: A meta-analysis of randomized controlled trials

submitted by: mpase
Background: Multivitamins are the most commonly used supplement in the developed world. Recent epidemiological findings suggest multivitamin use increases the risk of mortality. Objectives: We aimed to determine whether multivitamin-multimineral treatment, used for primary or secondary prevention, increases the risk of mortality in independently living adults. Methods: We performed a meta-analysis of randomized, controlled trials. Multiple electronic databases were systematically searched...
Authors: Helen Macpherson, Andrew Pipingas, Matthew Pase

Effects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of randomized controlled trials

submitted by: tom_witches
Background: It is currently unclear whether altering the carbohydrate-to-protein ratio of low-fat, energy-restricted diets augments weight loss and cardiometabolic risk markers. Objective: The objective was to conduct a systematic review and meta-analysis of studies that compared energy-restricted, isocaloric, high-protein, low-fat (HP) diets with standard-protein, low-fat (SP) diets on weight loss, body composition, resting energy expenditure (REE), satiety and appetite, and...
Authors: Thomas Wycherley, Lisa Moran, Peter Clifton, Manny Noakes, Grant Brinkworth

Greater whole-grain intake is associated with lower risk of type 2 diabetes, cardiovascular disease, and weight gain

submitted by: sarachacko
Whole-grain and high fiber intakes are routinely recommended for prevention of vascular diseases; however, there are no comprehensive and quantitative assessments of available data in humans. The aim of this study was to systematically examine longitudinal studies investigating whole-grain and fiber intake in relation to risk of type 2 diabetes (T2D), cardiovascular disease (CVD), weight gain, and metabolic risk factors. We identified 45 prospective cohort studies and 21...
Authors: Sara A. Chacko, Eva Qing Ye, Elizabeth L. Chou, Matthew Kugizaki, Simin Liu

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis

submitted by: Laura Tripkovic
Background: Currently, there is a lack of clarity in the literature as to whether there is a definitive difference between the effects of vitamins D2 and D3 in the raising of serum 25-hydroxyvitamin D [25(OH)D]. Objective: The objective of this article was to report a systematic review and meta-analysis of randomized controlled trials (RCTs) that have directly compared the effects of vitamin D2 and vitamin D3 on serum 25(OH)D concentrations in humans. Design: The ISI Web of Knowledge...
Authors: Laura Tripkovic, Helen Lambert, Kathryn Hart, Colin P Smith, Giselda Bucca, Simon Penson, Gemma Chope, Elina Hypponen, Jacqueline Berry, Reinhold Vieth, Susan Lanham-New

GSC 9: Open discussion Metagenomes, Metadata, Metaanalysis, Models and MetaInfrastructure (M5) Roadmap session

submitted by: psterk1

9th Genomic Standards Consortium Workshop at JCVI, Rockville, MD, USA, April 28-30, 2010 (http://gensc.org/gc_wiki/index.php/GSC_9).
GSC 9: Open discussion Metagenomes, Metadata, Metaanalysis, Models and MetaInfrastructure (M5) Roadmap session

Workflows and M5

submitted by: psterk1

9th Genomic Standards Consortium Workshop at JCVI, Rockville, MD, USA, April 28-30, 2010 (http://gensc.org/gc_wiki/index.php/GSC_9).
Workflows and M5 presented by Jeff Grethe, University of California, San Diego