Is there a dose-response relation of dietary glycemic load to risk of type 2 diabetes? Meta-analysis of prospective cohort studies

submitted by: Geoffrey Livesey
Background: Although much is known about the association between dietary glycemic load (GL) and type 2 diabetes (T2D), prospective cohort studies have not consistently shown a positive dose-response relation. Objective: We performed a comprehensive examination of evidence on the dose response that links GL to T2D and sources of heterogeneity among all prospective cohort studies on healthy adults available in the literature. Design: We conducted a systematic review of all prospective...
Authors: Geoffrey Livesey, Richard Taylor, Helen Livesey, Simin Liu

All-cause mortality and periodontitis in 60–70-year-old men: a prospective cohort study

submitted by: Gerrylinden
Objective: To investigate the association between periodontitis and mortality from all causes in a prospective study in a homogenous group of 60-70 year-old Western European men. Methodology: A representative sample of 1400 dentate men, (mean age 63.8 SD 3.0 years), drawn from the population of Northern Ireland, had a comprehensive periodontal examination between 2001 and 2003. Men were divided into thirds on the basis of their mean periodontal attachment loss (PAL). The primary endpoint,...
Authors: Gerard Linden, Katie Linden, John Yarnell, Alun Evans, Frank Kee, Christopher Patterson

Breast Cancer -- It Doesn't Just Strike Women

submitted by: mdanderson
There were about 1,970 new cases of invasive breast cancer diagnosed among men in the United States in 2010. Yet, because of the lack of awareness, diagnosis normally happens at a late stage. Breast cancer is branded a female disease, so males must brave the pink ribbons, women-only waiting rooms, etc. There are similarities and differences in male and female breast cancer. Sharon Giordano, M.D., associate professor and internist in the Department of Breast Medical Oncology at MD...

Systems biology of the mitotic spindle

submitted by: JCB
A novel high-throughput screening approach that combines yeast mutant arrays with high-content imaging provides fresh insights into mitotic spindle disassembly. This biosights episode presents the paper by Vizeacoumar et al. from the January 11, 2010 issue of The Journal of Cell Biology, and includes interviews with authors Brenda Andrews and Charles Boone, and JCB editorial board member John Aitchison. Produced by Eun Choi. Read the complete paper at:...