New Drugs Target Melanoma

submitted by: mdanderson

Two new drugs provide the first new treatments for melanoma in years. However, they don't help everyone and resistance can develop. Michael Davies, M.D., Ph.D., of MD Anderson's Department of Melanoma, discusses next steps.

Targeted Therapy Promising For Cancer Patients

submitted by: mdanderson

Casey Carleton, a patient with metastatic melanoma explains his experience and success on Phase 1 clinical trial. Customizing targeted therapies to each tumor's molecular characteristics, instead of a one-size-fits-all approach by tumor type, may be more effective for some types of cancer, according to research conducted by The University of Texas MD Anderson Cancer Center. http://bit.ly/khHJA7

Study details first therapeutic melanoma vaccine

submitted by: mdanderson
Scientists, led by Patrick Hwu, M.D., of MD Anderson Cancer Center, and Douglas Schwartzentruber, M.D., of Goshen Center for Cancer Care, have developed a vaccine for advanced melanoma. When combined with Interleuken-2, the cocktail stimulates the body's immune system to recognize and ultimately fight cancer cells. Drs. Hwu and Schwartzentruber explain their findings, which are published in the New England Journal of Medicine, and discuss other recent advances in the treatment and research...

Melanoma: is hair the root of the problem?

submitted by: agarcia5

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Authors: Angela Gomez garcia, Christine Mclaren, Frank Meyskens

Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility.

submitted by: Ashaniw
We have previously shown that Wnt5A-mediated signaling can promote melanoma metastasis. It has been shown that Wnt signaling is antagonized by the protein Klotho, which has been implicated in aging. We show here that in melanoma cells, expressions of Wnt5A and Klotho are inversely correlated. In the presence of recombinant Klotho (rKlotho), we show that Wnt5A internalization and signaling is decreased in high Wnt5A-expressing cells. Moreover, in the presence of rKlotho, we observe an...
Authors: Tura Camilli, Mai Xu, Michael O'connell, Bonnie Chien, Brittany Frank, Sarah Subaran, Fred Indig, Pat Morin, Stephen Hewitt, Ashani Weeraratna

Wnt/beta-catenin signaling is stimulated by alpha-Melanocyte-Stimulating Hormone in melanoma and melanocyte cells: implication in cell differentiation.

submitted by: bbellei
Wnt/?-catenin signaling plays important roles in many developmental processes including neural crest-derived melanocyte development and migration. However, the effective contribution of Wnt/?-catenin pathway in melanogenesis in adult human melanocytes has not been fully elucidated. Here, we report that in melanoma cells and in normal human melanocytes melanogenesis stimulation by ?-MSH induces phosphorylation of ?-catenin-Ser675 and stabilization of ?-catenin protein. Activation of PKA by...
Authors: Barbara Bellei

Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis

submitted by: gwalker
We report on a systematic analysis of genotype-specific melanocyte (MC) UVR responses in transgenic mouse melanoma models along with tumour penetrance and comparative histopathology. pRb or p53 pathway mutations cooperated with NrasQ61K to transform MCs. We previously reported that MCs migrate from the follicular outer root sheath into the epidermis after neonatal UVR. Here, we found that Arf or p53 loss markedly diminished this response. Despite this, mice carrying these mutations...
Authors: Graeme Walker, Blake Ferguson

Sunscreen prevention of melanoma in man and mouse

submitted by: hlpklug

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Authors: Glenn Merlino, Edward c De fabo, Margaret a Tucker, Heather lp Klug, Thomas r Fears, Miriam r Anver, Frances p Noonan, Cari Graff-cherry, Janet a Tooze

Genes, cancer and the lymphatic system

submitted by: MarkShriver

Current Yale University Graduate Student and Morehouse College alumnus, Dennis Jones discusses some of his research on the BMX gene in a mouse model of cancer progression.

MELANOMA THERMOGRAPHY

submitted by: camdic

Thermography allows the investigator to create a 3 dimensional image based on infrared emissions from tissue. Warmer tissues show up as yellow and white, whereas darker colors represent cooler structures. Malignant tumors are metabolically active and appear yellow and white on the images.
Metastatic melanoma in left inguinal lymphonodes - metastatic melanoma in left leg -
Prof. Camillo O. Di Cicco, MD