First-year progress in MD Anderson’s Moon Shots Program

submitted by: mdanderson
The University of Texas MD Anderson Cancer Center in September 2012 announced its Moon Shots Program, an unprecedented effort to dramatically accelerate the pace of converting scientific discoveries into clinical advances that reduce cancer deaths. The program initially targets acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS); chronic lymphocytic leukemia (CLL); lung cancer; melanoma; prostate cancer; and triple-negative breast and high-grade serious ovarian cancers....

Melanoma Moon Shot Annual Report 2013

submitted by: mdanderson
The University of Texas MD Anderson Cancer Center in September 2012 launched its Moon Shots Program, an ambitious and comprehensive action plan to dramatically accelerate the pace of converting scientific discoveries into clinical advances that reduce cancer deaths. Initial moon shot cancers are breast and ovarian; acute myeloid leukemia and myelodysplastic syndromes; chronic lymphocytic leukemia; lung; melanoma and prostate cancer. Jeffrey Gershenwald, M.D., professor in MD Anderson's...

Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates UV induced melanocyte homeostasis

submitted by: arup.indra
Keratinocytes contribute to melanocyte activity by influencing their microenvironment, in part, through secretion of paracrine factors. Here we discovered that p53 directly regulates Edn1 expression in epidermal keratinocytes and controls UV-induced melanocyte homeostasis. Selective ablation of EDN1 in murine epidermis (EDN1ep-/-) does not alter melanocyte homeostasis in newborn skin but decreases dermal melanocytes in adult skin. Results showed that keratinocytic EDN1 in a non-cell...
Authors: Daniel J. Coleman, Gitali Ganguli-Indra, Stephen Hyter, Arup Indra, Steven Ma, Gary F. Merrill, Masashi Yanagisawa

Tanning beds increase risk of skin cancer for teens

submitted by: mdanderson

The World Health Organization lists indoor tanning beds and lamps as carcinogens, yet many teenagers continue to believe that indoor tanning helps them look their best. Dennis Hughes, M.D., Ph.D., associate professor in Pediatrics at The University of Texas MD Anderson Cancer Center, explains how tanning beds increase your risk of developing skin cancers such as squamous cell carcinoma, basal cell carcinoma and melanoma, the most deadly form.

UT MD Anderson Cancer Center launches unprecedented Moon Shots Program to increase patient survival during the next decade

submitted by: mdanderson
Inspired by America’s drive a generation ago to put a man on the moon, MD Anderson’s Moon Shots Program is a highly-concentrated effort to rapidly and dramatically decrease suffering and death in several major cancers, including acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS); chronic lymphocytic leukemia (CLL); lung; melanoma; prostate and two cancers linked at the molecular level: triple-negative breast and ovarian. Focused teams are building on new technology and...

Learn the facts about melanoma

submitted by: mdanderson

Melanoma is on the rise in the United States. In the United States 2011, one person died of melanoma every hour. Learn to protect yourself from melanoma and know skin cancer warning signs. Ana Mercedes Ciurea, M.D., assistant professor in Dermatology at MD Anderson Cancer Center, discusses these topics as well as shares what population is most susceptible to developing melanoma.

Tips to Help Kids Avoid Adult Cancers

submitted by: mdanderson

Beverly Gor, Ed.D., postdoctoral fellow in the Center for Health Equity and Evaluation Research at The University of Texas MD Anderson Cancer Center, discusses healthy lifestyle choices you can make for your children to help prevent the development of certain adult cancers; such as prostate, breast and colon. Gor stresses the importance of healthy nutrition and exercise to reduce the risk of developing cancer later in life.

Skin Cancer of the Eye – Uveal Melanoma

submitted by: mdanderson

Uveal melanoma is a very rare cancer that forms on the eye’s skin tissue, usually in the back part of the eye under the retina (choroid). Sapna Patel, M.D., Assistant Professor in the Department of Melanoma Medical Oncology at The University of Texas MD Anderson Cancer Center, discusses the causes, symptoms and treatment of uveal melanoma. Patel also explains why it is important for everyone to have their eyes examined, even if your vision is 20/20.

Embryonic stem-cell-preconditioned microenvironment induces loss of cancer cell properties in human melanoma cells

submitted by: cmjones
The cancer microenvironment affects cancer cell proliferation and growth. Embryonic stem (ES)-preconditioned 3-dimensional (3-D) culture of cancer cells induces cancer cell reprogramming and results in a change in cancer cell properties such as differentiation and migration in skin melanoma. However, the mechanism has not yet been clarified. Using the ES-preconditioned 3-D microenvironment model, we provide evidence showing that the ES microenvironment inhibits proliferation and...
Authors: M. o. Kim, S. h. Kim, N. Oi, M. h. Lee, D. h. Yu, D. j. Kim, E. j. Cho, A. m. Bode, Y. y. Cho, T. g. Bowden, Z. Dong

New Drugs Target Melanoma

submitted by: mdanderson

Two new drugs provide the first new treatments for melanoma in years. However, they don't help everyone and resistance can develop. Michael Davies, M.D., Ph.D., of MD Anderson's Department of Melanoma, discusses next steps.