Antibiotic resistant hospital bacteria

submitted by: COMED2010
MOSAR aims to significantly advance our knowledge regarding the control of antimicrobial resistance of bacteria responsible for major and emerging nosocomial diseases in hospitals, which are now spreading into communities. MOSAR will examine the factors determining the dynamics of spread of AMRB within healthcare facilities and the relative efficacity and medicoeconomic impact of control strategies. The resulting new knowledge will be disseminated to caregivers and health policy makers and...

Intestinal microbiota and human health

submitted by: COMED2010
The central objective of the MetaHit project is to establish associations between the genes of the human intestinal microbiota and human health and disease. The research work is focused on two disorders of increasing importance in Europe, Inflamatory Bowel Disease (IBD) and obesity. First, we need to establish an extensive reference catalog of microbial genes and genomes present in the human intestine. The second challenge is to develop tools to determine which genes and genomes of the...

How to define human biological age

submitted by: COMED2010
Towards establishing biomarkers of human ageing “European Study to Establish Biomarkers of Human Ageing (MARK-AGE)” brings together 26 groups located in 14 European countries. The scientific background is the following: The rate of ageing in humans is not uniform, age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Within the...

Dogs help to decode human DNA

submitted by: COMED2010
Dogs are more than man’s best friends; they can help us unravelling the genetic of diseases such as cancer, epilepsy, cardiovascular troubles, diabetes etc. Living in the same environment human and dogs are suffering from the same diseases but the genetic complexity is quite lower in dogs. During 4 years 20 veterinary schools spread across Europe are working together to collect 10.000 blood samples from purebred dogs affected by similar diseases as human. The analysis of the genome of...

New heart valve development for children

submitted by: COMED2010
The general objective of the LifeValve project is to develop a new therapeutic strategy to treat heart valve disease. In particular, the development of a tissue engineered living heart valve, with the capacity of growth in accordance with the growths of children, which can be implanted without an operation by minimally invasive catheter technology will be addressed. The rationale for first focussing on paediatric applications is twofold: First, a novel, tissue engineered living heart valve...

Joint efforts in the fight against stroke

submitted by: COMED2010

The exploration of neurovascular dysfunction and the perfection of thrombolytic therapy in stroke are two core areas of research pursued by scientists of the European Stroke Network.

Novel antimalarial drug development

submitted by: COMED2010
The main objective of the AntiMal Integrated Project is to generate novel antimalarial drugs with potential for use in humans, specifically to progress candidate molecules to the “first time into humans” stage of drug development. To achieve this goal, leading groups of malaria researchers from Europe and Africa with expertise in malaria biology, chemotherapy and drug development have come together to exploit new scientific and political opportunities to secure the development of a...