The Surprising World of Prion Biology--A New Mechanism of Inheritance: Part 2: Antigen Presentation and Dendritic Cells (53:35)

submitted by: scivee-team
The immune system is charged with protecting us from invading microorganisms, a task that falls to a complex array of highly specialized cell types spread throughout the body but that must work together as an integrated system. How they accomplish perform their functions can be wonderfully understood by probing the basic mechanisms governing their activities. In the first video, we will consider the overall organization of the immune response in cellular terms, the innate immune system...

The Surprising World of Prion Biology--A New Mechanism of Inheritance: Part II (26:08)

submitted by: scivee-team
Part II: In the case of the yeast prion [PSI], the misfolding of the Sup35 protein results in a simple change in metabolism. When misfolded Sup35 is passed from mother cells to their daughters, this metabolic change is inherited. This unusual genetic mechanism changes the organism in a heritable way due to a self-perpetuating change in protein conformation with no change in its DNA. The mechanism of epigenetic inheritance we have delineated provides a one-step process for the acquisition of...