AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis

submitted by: JCB
Specialized cell types exploit endosomal trafficking to deliver protein cargoes to cell type–specific lysosome-related organelles (LROs), but how endosomes are specified for this function is not known. In this study, we show that the clathrin adaptor AP-1 and the kinesin motor KIF13A together create peripheral recycling endosomal subdomains in melanocytes required for cargo delivery to maturing melanosomes. In cells depleted of AP-1 or KIF13A, a subpopulation of recycling endosomes...
Authors: Cédric Delevoye, Ilse Hurbain, Danièle Tenza, Jean-baptist Sibarita, Stéphanie Uzan-gafsou, Hiroshi Ohno, Willie Geerts, Arie Verkleij, Jean Salamero, Graça Raposo