Jeroen Raes, European Molecular Biology Laboratory Comparative metagenomics is a powerful tool to detect environment-specific adaptation of the communities that inhabit them. However, a wide range of technical and biological interfering factors hamper the correct interpretation of comparative metagenomics results. Here, I will describe some of these factors and pitfalls and propose a minimal metagenome sequence analysis standard (MINIMESS) to cope with these issues. This suggested additional,...