Trypanosoma cruzi in the chicken model. Autoimmune Chagas-like Heart Disease

submitted by: Antonio Teixeira
he administration of anti-trypanosome nitroderivatives curtails Trypanosoma cruzi infection in Chagas disease patients, but does not prevent destructive lesions in the heart. This observation suggests that an effective treatment for the disease requires understanding its pathogenesis. To understand the origin of clinical manifestations of the heart disease we used a chicken model system in which infection can be initiated in the egg, but parasite persistence is precluded. T. cruzi...
Authors: Teixeira Antonio rl, Gomes Clever, Nitz Nadjar, Alessandro sousa, Alves Roseneide, Sousa Alessandro, Cambraia Maria carolina, Cordeiro Ciro, Bernal Francisco m, Rosa Ana cassia, Hejnar Jiri, Leonardecz Eduardo, Hecht Mariana m

Intracellular Parasitism by Trypanosoma cruzi and Leishmania": Part 3: Current Research: Strategies for Cell Invasion and Intracellular Survival (33:43)"

submitted by: video_collector

In the third part of this lecture, I will discuss current work from our laboratory on mechanisms used by the intracellular parasites Trypanosoma cruzi and Leishmania to interact with mammalian cells. In addition to clarifying specific molecular strategies used by these parasites to infect and survive within host cells, these studies also led, in some instances, to unexpected insights on novel pathways regulating mammalian cell function.

Intracellular Parasitism by Trypanosoma cruzi and Leishmania by Norma Andrews, April 2007 - Part 1: Trypanosoma cruzi and Chagas' Disease (19:23)

submitted by: video_collector
Trypanosoma cruzi and Leishmania are closely related intracellular protozoan parasites that cause serious diseases throughout the world. In the first part of this lecture, I will present background material on the biology of Trypanosoma cruzi and the history of its discovery as an important agent of human disease in Latin America. I will also discuss the main characteristics of the disease, and the current efforts to stop human transmission. For more information see:...