Functional reconstitution of NKT cells in HIV-1 infected individuals

submitted by: dzhoumda
A reduction in the generation of lung-homing TB-specific effector memory CD4 Th1 cells after HIV infection is a key factor in the increased risk of active TB disease. Natural killer T cells are an innate type of immune cells responsible for first line of anti-viral defense, which may “jump-start” the adaptive immune responses and regulate the Th1 versus Th2 differentiation of CD4 helper T cells, through their unique ability to activate antigen-presenting cells (e.g., DCs). The regulatory...

Curbing the Killer Instinct

submitted by: JCB
Natural Killer (NK) cells distinguish target cells from surrounding healthy tissue by integrating signals from a variety of activating and inhibitory receptors. Abeyweera et al. reveal that signals from inhibitory receptors limit NK cell activity by remodeling contacts with potential targets and inducing NK cell retraction. This biosights episode presents the paper by Abeyweera et al. from the February 21st, 2011, issue of The Journal of Cell Biology, and includes an interview with senior...