Microtubules Keep Tumor Cells Breathing Easy

submitted by: JCB
The transcription factor HIF-1α is essential for a cell's response to low oxygen conditions. Carbonaro et al. demonstrate that production of HIF-1α protein is regulated by dynamic microtubules and that microtubule-targeting drugs shift HIF-1α mRNA into cytoplasmic P-bodies, where its translation is repressed by miRNAs. This biosights episode presents the paper by Carbonaro et al. from the January 10, 2011, issue of The Journal of Cell Biology, and includes an interview with authors Marisa...

Immunoprecipitation in 40 min's - Dynabeads vs. Sepharose/agarose

submitted by: andrewinoslo

See these two technologies go head to head in a side-by-side time elapsed protocol

Magnetic Separation

submitted by: andrewinoslo

Magnetic separation technology was pioneered by Dynal for the separation of biomagnetic material. Dynabeads technology supports genomics, transcriptomics, proteomics, diagnostics, basic research, clinical cell