CKIδ Decentralizes the Centrosome

submitted by: JCB
When a T cell encounters a target antigen-presenting cell, the lymphocyte's centrosome relocalizes to a specialized contact between the two cells called the immunological synapse. Zyss et al. reveal that casein kinase Iδ helps to reposition the centrosome in activated T cells, perhaps by working with the microtubule plus-end binding protein EB1 to regulate microtubule growth. This biosights episode presents the paper by Zyss et al. from the November 28, 2011, issue of The Journal of Cell...

Curbing the Killer Instinct

submitted by: JCB
Natural Killer (NK) cells distinguish target cells from surrounding healthy tissue by integrating signals from a variety of activating and inhibitory receptors. Abeyweera et al. reveal that signals from inhibitory receptors limit NK cell activity by remodeling contacts with potential targets and inducing NK cell retraction. This biosights episode presents the paper by Abeyweera et al. from the February 21st, 2011, issue of The Journal of Cell Biology, and includes an interview with senior...