The Obesity Paradox, Cardiorespiratory Fitness, and Coronary Heart Disease

submitted by: WentzMR

Dr. Carl (Chip) Lavie, a cardiologist from Ochsner Clinic in New Orleans, LA, discusses an article appearing in the May 2012 issue of Mayo Clinic Proceedings, which provides further evidence for the validation of the obesity paradox. Previous study results may be misleading if fitnessof the patient is not also considered.
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Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up

submitted by: shaunaharte
ABSTRACT Background: We recently reported that the elevated blood pressure (BP) observed in patients with cardiovascular disease who are homozygous for the 677C/T polymorphism (TT genotype) in the gene encoding methylenetetrahydrofolate reductase (MTHFR) was responsive to supplementation with riboflavin—the cofactor for MTHFR. Objective: The objective was to investigate the effect of riboflavin on BP targeted at patients with the TT genotype 4 y after initial investigation, during...
Authors: Carol P Wilson, Mary Ward, Helene McNulty, J J Strain, Tom G Trouton, Geraldine Horigan, John Purvis, John M Scott

My Symposia Interview: Drugs and Devices - Novel Targets in Hypertension

submitted by: OxfordJournals

Luis Ruilope Michael Böhm in conversation with Frank Ruschitzka
Drugs and Devices - Novel Targets in Hypertension

Stress and Hypertension

submitted by: ZRT_Laboratory

Dr. Sanjay Kapur explains the relation between stress and hypertension.

Clinical Pearls in Men's Health.

submitted by: mcgheekkm

Dr. Beckman discusses his article appearing in the July 2010 issue of Mayo Clinic Proceedings commenting on three cases involving men's health.

Sodium Channels and Pain

submitted by: alex01

S. Waxman, MD, PhD. - Medical need for new analgesics is discussed by S. Waxman (Yale University) who evaluated the role of selective subtypes of sodium channels, particularly 1.7 and 1.8 subtypes, in the perception of pain. There is an unmet medical need for drugs to treat chronic pain and inhibitors of
selective sodium channels are in development as novel analgesics.

Calcium Channels

submitted by: alex01

Dr. Catterall describes autoinhibitory control of cardiac L-type cardiac calcium channels by protein
phosphorylation and macromolecular signaling as well as regulation of P/Q type calcium currents in
neurons. His research suggests novel targets for drugs affecting cardiovascular or central nervous

Is there preferential loss of aortic baroreceptor C-fibre activity during the development of atherosclerosis?

submitted by: Mike_Turner

Michael Turner shares his poster presentation at the Experimental Biology 2008 conference.

The exercise pressor reflex in hypertensive humans

submitted by: msausen

Mark Sausen shares his poster presentation at the Experimental Biology 2008 conference.