Supplementing a low protein diet with dibasic amino acids increases urinary calcium excretion in young women

submitted by: jld03009
Increasing dietary protein within a physiologic range stimulates intestinal calcium absorption, but it is not known if specific amino acids or dietary protein as a whole are responsible for this effect. Therefore, we selectively supplemented a lowprotein (0.7 g/kg) diet with either the calcium-sensing receptor-activating amino acids (CaSR-AAAs) L-tryptophan, L-phenylalanine, and L-histidine, or the dibasic amino acids (DAAs) L-arginine and L-lysine, to achieve intakes comparable to the...
Authors: Jessica Bihuniak, Rebecca Sullivan, Christine Simpson, Donna Caseria, Tania Huedo-Medina, Kimberly O’Brien, Jane Kerstetter, Karl Insogna

A diet rich in high glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles through modulating mitochondrial function

submitted by: Andrew Chapple
Background: Observational and experimental studies suggest that diets rich in cruciferous vegetables and glucosinolates may reduce the risk of cancer and cardiovascular disease (CVD). Objective: We tested the hypothesis that a 12-wk dietary intervention with high-glucoraphanin (HG) broccoli would modify biomarkers of CVD risk and plasma metabolite profiles to a greater extent than interventions with standard broccoli or peas. Design: Subjects were randomly assigned to consume 400 g...
Authors: Charlotte Armah, Maria Traka, Jack Dainty, Marianne Defernez, Astrid Janssens, Wing Leung, John Potter, Richard Mithen

Association between water consumption and body weight outcomes: a systematic review

submitted by: Rebecca
BACKGROUND Drinking water is often applied as a dietary means for weight loss and overweight/obesity prevention, but no evidence-based recommendation exists for this indication. OBJECTIVE We summarized the existing evidence on the association between water consumption and body weight outcomes in adults of any body weight status. DESIGN In a systematic review, we retrieved studies from 4 electronic databases (MEDLINE, EMBASE, CINAHL, and COCHRANE), cross-references by PubMed functions...
Authors: R Muckelbauer, G Sarganas, A Grüneis, J Müller-Nordhorn

Weight-loss diets in people with type 2 diabetes and renal disease: a randomized controlled trial of the effect of different dietary protein amounts

submitted by: Peter Clifton
ABSTRACT Background: Higher-protein weight-loss diets (defined as >25% of energy as protein) are not recommended for individuals with type 2 diabetes because of their potential adverse effect on renal function. Objective: We aimed to examine the effect of such diets on renal function over 12 mo in people with type 2 diabetes and early renal disease. Design: Overweight and obese people with type 2 diabetes were screened to identify those with an albumin:creatinine ratio from 3 to...
Authors: David Jesudason, Eva Pedersen, Peter Clifton

Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: A randomized controlled trial

submitted by: petersonca
Background: Obese adolescents are at a greater risk for vitamin D deficiency because the vitamin is thought to be sequestered by excess adipose tissue. Poor vitamin D status has been associated with a higher prevalence of the metabolic syndrome and/or type 2 diabetes in both adults and adolescents. Objective: To determine in obese adolescents the efficacy and safety of 4000 IU/day of vitamin D3; and if subsequent increased circulating concentrations of 25 hydroxyvitamin D [(25(OH)D] are...
Authors: Anthony Belenchia, Aneesh Tosh, Laura Hillman, Catherine Peterson

Vitamin D supplementation and calcium absorption during caloric restriction: a randomized double blind trial

submitted by: shapses
Background: Weight loss (WL) is associated with a decrease in calcium absorption and may be one mechanism that induces bone loss with weight reduction. Objective: Because vitamin D supplementation has been shown to increase true fractional calcium absorption (TFCA), the goal of this study was to examine the effect of vitamin D during WL or weight maintenance (WM). Design: A randomized, placebo-controlled, double-blind 6-wk study was conducted in 82 postmenopausal women [BMI (in kg/...
Authors: Sue Shapses, Deeptha Sukumar, Stephen Schneider, Yvette Schlussel, Robert Sherrell, M Paul Field, Hasina Ambia-Sobhan

Effects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of randomized controlled trials

submitted by: tom_witches
Background: It is currently unclear whether altering the carbohydrate-to-protein ratio of low-fat, energy-restricted diets augments weight loss and cardiometabolic risk markers. Objective: The objective was to conduct a systematic review and meta-analysis of studies that compared energy-restricted, isocaloric, high-protein, low-fat (HP) diets with standard-protein, low-fat (SP) diets on weight loss, body composition, resting energy expenditure (REE), satiety and appetite, and...
Authors: Thomas Wycherley, Lisa Moran, Peter Clifton, Manny Noakes, Grant Brinkworth

Effect of alginate supplementation on weight loss in obese subjects completing a 12-wk energy-restricted diet: a randomized controlled trial

submitted by: mekr@life.ku.dk
Background: Acute studies with alginate-based preloads suggested that these strong gelling fibers may induce increased feelings of satiety and reduce energy intakes. However, the long-term efficacy and safety of alginate supplementation on body weight regulation are lacking. Objective: The primary aim of the study was to investigate the effects in subjects of alginate supplementation in conjunction with energy restriction (2300 kcal/d) on loss of body weight and fat and, second, on...
Authors: Morten Georg Jensen, Mette Kristensen, Arne Astrup