Danger from the Wild: HIV, Can We Conquer It? Part 3: The Grand Challenge: Engineering Immunity (18:51)

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In this last segment, I describe another gene therapy strategy for HIV in which we propose to develop antibody-like proteins that can be expressed by a patient's B cells and will target the HIV virus for destruction. To achieve this objective, hematopoietic (blood) stem cells must to be targeted with the gene, which will ultimately develop into B cells that express the therapeutic molecule. The ultimate goal is to produce a life-long supply of anti-HIV neutralizing antibodies. In this...

Danger from the Wild: HIV, Can We Conquer It?": Part 2: Why Gene Therapy Might be a Reasonable Tool for Attacking HIV (30:08)"

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In part 2, I describe the growing health problem that is facing the world with the spread of HIV and the limitations of current drug therapies and vaccine strategies. We need new ideas for tackling this problem. Here and in the next segment, I describe bold strategies of using gene therapy to conquer HIV, The approach that I describe in this segment involves gene therapy to produce short hairpin RNAs (siRNA) that target the destruction of a critical co-receptor of HIV, which the viruses that...

Danger from the Wild: HIV, Can We Conquer It? by David Baltimore, Feb. 2007 - Part 1: Introduction to Viruses: HIV and Non-equilibrium Viruses (34:06)

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In this set of lectures, I describe the threat facing the world from the human immunodeficiency virus (HIV) and a bold proposal on how we might meet the challenge of eliminating this disease by engineering the immune system. In part 1, I provide a broad introduction to viruses, describing their basic properties and my own history of studying the replication RNA viruses which led to the discovery of reverse transcriptase. I also illustrate the distinguishing features of equilibrium viruses...

MacArthur Fellow 2008: Wafaa El-Sadr, physician

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Wafaa El-Sadr is an Infectious Disease Physician introducing multi-pronged treatment strategies for some of the most pressing pandemics of our time – HIV/AIDS and TB – diseases that often afflict people with the least access to quality health care. MacArthur Fellowships offer the opportunity for Fellows to accelerate their current activities or take their work in new directions. The unusual level of independence afforded to Fellows underscores the spirit of freedom intrinsic...

Return to Zambia MWV 17

submitted by: MicrobeWorld
The American Society for Microbiology is helping African nations foster a scientific community that is better able to address the current and future problems that threaten not only the local population, but the world at large. Like many African countries, Zambia and South Africa are deeply affected by HIV and tuberculosis, as well as a number of other infectious diseases. In March of 2008, ASM President Cliff Houston, Ph.D., traveled to Zambia and South Africa to gauge and assess the...

HIV/AIDS Education in America (MWV14)

submitted by: MicrobeWorld
In this episode of MicrobeWorld Video we ask some leading researchers, education specialists, and public health officials about the state of HIV/AIDS education in America and ideas they have to support the teaching of microbial evolution using the latest HIV/AIDS research ó all while instilling innovative prevention strategies. Filmed at a forum for educators on February, 11, 2008 at the Koshland Science Museum in Washington, D.C. and at San Diego State University, this episode features...

HIV Dermatology

submitted by: camdic

Objective: Study of cutaneous displays found during AIDS, spy of early diagnosis of disease.