Structural analysis of the evolution of steroid specificity in the mineralocorticoid and glucocorticoid receptors

submitted by: Michael Baker
Background The glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) evolved from a common ancestor. Still not completely understood is how specificity for glucocorticoids (e.g. cortisol) and mineralocorticoids (e.g. aldosterone) evolved in these receptors. Results Our analysis of several vertebrate GRs and MRs in the context of 3D structures of human GR and MR indicates that with the exception of skate GR, a cartilaginous fish, there is a...
Authors: Michael e Baker, Charlie Chandsawangbhuwana, Noah Ollikainen