Imatinib (Gleevec) as a Paradigm of Targeted Cancer Therapies: Part 3: Extending the Imatinib Paradigm (22:09)

submitted by: scivee-team

The lessons learned from the clinical trials of imatinib will be reviewed in this section. This will include examples of where imatinib has or has not worked, analysis of target expression versus activation and a discussion of how the success of imatinib can be translated to other malignancies. The section concludes with what this means for research to control or cure cancer in the coming decades.

Imatinib (Gleevec) as a Paradigm of Targeted Cancer Therapies: Part 2: Imatinib Resistance and Other Diseases Targeted by Imatinib (25:12)

submitted by: scivee-team
Although the majority of patients with CML respond well to imatinib, a minority of patients have relapsed. This part of the lecture will cover what has been learned about mechanisms of relapse and how this information has been translated into new therapies for patients with imatinib resistance. Although imatinib is a relatively specific inhibitor of the ABL kinase, a couple of other kinases, KIT and the platelet derived growth factor receptor are also inhibited by imatinib. This use of this...

Imatinib (Gleevec) as a Paradigm of Targeted Cancer Therapies by Brian Druker, March 2007 - Part 1: Chronic Myeloid Leukemia (CML) and Imatinib (33:54)

submitted by: video_collector
Imatinib (Gleevec) has become a paradigm for targeted cancer therapies. The first part of this lecture will describe the clinical features and the molecular pathogenesis of the disease for which imatinib was developed, chronic myeloid leukemia (CML). This overview will trace the history of the identification of the target of imatinib, BCR-ABL. The preclinical development of the BCR-ABL kinase inhibitor, imatinib and highly successful clinical trials of this agent for patients with CML will...