Polymorphisms in genes involved in folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia

submitted by: LUCIANA TOMITA
High folate intake has been suggested as an important factor for cancer prevention; however, previous studies on the relationship between folate intake, serum folate and plasma homocysteine are controversial. We conducted a hospital-based, case-control study in Brazil investigating associations between dietary and circulating vitamins B-6, B-12 and folate, homocysteine, genotypes of folate-metabolizing enzyme methylenetetrahydrofolate reductase [MTHFR C677T, A1298C],...
Authors: Luciana Tomita, Vania d'Almeida, Luisa Villa, Eduardo Franco, Marly Cardoso

A diet rich in high glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles through modulating mitochondrial function

submitted by: Andrew Chapple
Background: Observational and experimental studies suggest that diets rich in cruciferous vegetables and glucosinolates may reduce the risk of cancer and cardiovascular disease (CVD). Objective: We tested the hypothesis that a 12-wk dietary intervention with high-glucoraphanin (HG) broccoli would modify biomarkers of CVD risk and plasma metabolite profiles to a greater extent than interventions with standard broccoli or peas. Design: Subjects were randomly assigned to consume 400 g...
Authors: Charlotte Armah, Maria Traka, Jack Dainty, Marianne Defernez, Astrid Janssens, Wing Leung, John Potter, Richard Mithen

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women

submitted by: enphpdom
Background: Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were exposed to famine or who conceived in the Gambian rainy season. Objective: The objective was to understand the seasonality of DNA methylation patterns in rural Gambian women. We studied natural...
Authors: P Dominguez-Salas, AM Prentice

Around the Nucleus

submitted by: ahernk

This video is a surreal presentation of a Metabolic Melody by Kevin Ahern (www.davincipress.com/metabmelodies.html for more info). The tune is The Beatle's "Across the Universe." The lyrics and video are by Kevin Ahern and the recording is by David Simmons

Correcting for Inflammation Changes Estimates of Iron Deficiency among Rural Kenyan Preschool Children

submitted by: ebogrant5
The assessment of iron status where infections are common is complicated by the effects of inflammation on iron indicators and in this study we compared approaches that adjust for this influence. Blood was collected in 680 children (aged 6–35 mo) and indicators of iron status [(hemoglobin (Hb), zinc protoporphyrin (ZP), ferritin, transferrin receptor (TfR), and TfR/ferritin index)] and subclinical inflammation [(the acute phase proteins (APP) C-reactive protein (CRP), and a-1-acid...
Authors: Frederick Grant, Parminder Suchdev, Rafael Flores-Ayala, Conrad Cole, Usha Ramakrishnan, Laird Ruth, Reynaldo Martorell

Neil Miller on “Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis”

submitted by: JGI

Neil Miller, Deputy Director of Software Engineering at the National Center for Genome Resources, discusses a monozygotic twin study on June 2, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM.

New Methods from the Berkeley Phylogenomics Group

submitted by: ruchira

Here we present two new algorithms hosted within the PhyloFacts phylogenomic encyclopedias.

Larry Kedes on "The $10M Archon Genomic X PRIZE and Data Validation"

submitted by: JGI

Larry Kedes from the X PRIZE Foundation and the University of Southern California speaks at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM on May 28, 2009.

A Genomic Encyclopedia of Bacteria and Archaea (GEBA) and the Search for the Dark Matter of the Biological Universe

submitted by: dougramsey
There is a glaring gap in microbial genome sequence availability – the currently available genome sequences show a highly biased phylogenetic distribution compared to the extent of microbial diversity known today. This bias has resulted in major limitations in our knowledge of microbial genome complexity and our understanding of the evolution, physiology and metabolic capacity of microbes. Although there have been small efforts in sequencing genomes from across the tree of life for...