Challenges in Ecological Metagenomics

submitted by: dougramsey
Since the first metagenomics study was published 17 years ago, the ability to make ecological inferences has been limited by sequencing throughput and the ability to analyze the data. Yet, if the potential of metagenomics to help us decipher the structure and function of microbial ecosystems is to be realized, it is essential that our bioinformatics tools motivate our sequencing efforts. This is analogous to the bioinformatics advances that were made to accelerating the sequencing of the...

Implementing MIGS/MIMS: The Genomic Contextual

submitted by: dougramsey
The MIGS/MIMS checklist developed by the Genomic Standards Consortium (GSC) aims to enrich our ever growing data collection of genomic and metagenomic sequences. Therefore, the checklist defines what minimal list of contextual data attributes has to be added to the sequences in order to conform to the MIGS/MIMS specification. However, MIGS/MIMS itself does not specify how the contextual data should be documented; thus the GSC is developing the Genomic Contextual Data Markup Language (GCDML),...

Integrated Information System for Genomic and Metagenomic Data Analysis at National Center for Biotechnology Information (NCBI)

submitted by: dougramsey
Recent advances in biotechnology and bioinformatics has provided a flood of genomic data and tremendous growth in the number of associated data sets. Sequencing projects now include draft assemblies, complete genomes, comparative genomics, and metagenomics where genetic material is sequenced directly from environmental samples. The NCBI provides integrated systems for data storage, retrieval, and analysis. GenBank, an archival database of DNA sequences, contains consensus sequences assembled...

New York-SGX Research Center for Structural Genomics

submitted by: dougramsey

Brief Report on Collaboration with Gerlt/Raushel P01 Consortium

Epigenomics of Cancer - Prof. Wei Li (Part 1, 2009)

submitted by: ralanharris

Prof. Wei Li lectures on studies of transcription factor binding sites and histone modifications using ChIP-chip and Chip-seq assays. Part of the Computer Aided Discovery Methods 2009 course offered at Baylor College of Medicine.

Advances to the Biochemical, Genetic and Genomic (BiGG) Database

submitted by: jypark
The BiGG database is a widely used resource for sharing genome-scale metabolic reconstructions. BiGG integrates several published genome-scale metabolic networks into one resource with standard nomenclature which allows components to be compared across different species. Furthermore, BiGG contains links to several publicly available databases where additional information can be found and integrated. In addition, BiGG contains a customized export tool that enables the generation of SBML...

Challenges in Automated Assignment of Function for Proteins From the Genome Projects

submitted by: WomenInBioinformatics

Patricia Babbitt, Ph.D. Professor of Biopharmaceutical Sciences and Pharmaceutical Chemistry

University of California - San Francisco