gene expression

Describes how to use SPELL (Serial Pattern of Expression Levels Locator), a query-driven search engine for large gene expression microarray compendia. Users will learn how to perform a search using a set of genes, download data, and show expression levels for a single gene.

Gene expression measurement during treatment with Cisplatin for breast cancer.

Tuning Gene's Expression to Understand Its Function - Scientists build a synthetic gene circuit with negative feedback to precisely control gene's activity.

In Part 2: Telling the back from the front or what the chordates invented, Marc Kirschner (Harvard Medical School) discusses why we look like invertebrate animals turned upside down, i.e. vertebrates have their central nervous system on their backs and invertebrates have it on their bellies.

Further studies have shown that the NC cells which participate in facial skeletogenesis correspond to the anteriormost region of the body axis where the genes of the Hox cluster are not expressed. If the forced expression of Hoxa2, Hoxa3 and Hoxb4 (the most anteriorly expressed Hox genes) is induced in this part of the neural fold, brain development is deeply affected with anencephaly and no skeletogenesis takes place in the face which fails to develop. This phenotype is reproduced when the...

Genomic association study (CHIP-Seq) of Liver X receptors beta in combination with gene expression analysis presented by Lana Garmire, Bioengineering, UC San Diego

The FLUX CAPACITOR : next generation sequencing technologies provide an unprecedented capacity for surveying the nucleic acid content of cells. This profound sequencing depth may allow in particular for exhaustively sequencing through the large dyanimc range of RNA abundances in the cell, overcoming limitations imposed by current (random) clone selection approaches. However, the very short reads produced by the most cost-effective such technologies make the reconstruction of complete RNA...

Prof. Wei Li lectures on studies of transcription factor binding sites and histone modifications using ChIP-chip and Chip-seq assays. Part of the Computer Aided Discovery Methods 2009 course offered at Baylor College of Medicine.

An introduction to computational methods for analyzing gene expression data by Chris Miller. This was presented as a lab within the Computer Aided Discovery Methods course offered within the Graduate Program at Baylor College of Medicine.

Michael Rogawski (University of California, Davis) summarizes his research on the antiepileptic activity of neurosteroids (e.g. ganaxolone, allopregnanolone). They are allosteric modulators of GABAA receptors and are active in many models of epilepsy. They are expected, however, to be most effective in catamenial epilepsy, infantile spasms or adult partial seizures. National Institutes of Health (NIH) is currently sponsoring a clinical trial of progesterone (precursor of allopregnanolone)...