Todd Smith (PerkinElmer) at the 2012 SFAF Meeting

submitted by: JGI

Todd Smith on "The PerkinElmer Omics Laboratory" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance

submitted by: tekn-ada
Background: Differential gene expression in adipose tissue during diet-induced weight loss followed by a weight stability period is poorly characterized. Markers of these processes may provide a deeper understanding of underlying mechanisms. Objective: We aimed to identify differentially expressed genes in human adipose tissue during weight loss and weight maintenance after weight loss. Design: RNA from subcutaneous abdominal adipose tissue from 9 obese subjects was analyzed by using a...
Authors: Lovisa Johansson, Anders Danielsson, Hemang Parikh, Maria Klintenberg, Fredrik Norström, Leif Groop, Martin Ridderstråle

SPELL at SGD

submitted by: yeastgenome

Describes how to use SPELL (Serial Pattern of Expression Levels Locator), a query-driven search engine for large gene expression microarray compendia. Users will learn how to perform a search using a set of genes, download data, and show expression levels for a single gene.

Time-resolved monitoring of the transcriptome of MCF-7 breast cancer cells during the emergence of cisplatin resistance

submitted by: martin_unibonn

Gene expression measurement during treatment with Cisplatin for breast cancer.

Tuning Gene's Expression

submitted by: mdanderson

Tuning Gene's Expression to Understand Its Function - Scientists build a synthetic gene circuit with negative feedback to precisely control gene's activity.

The Origin of Vertebrates - Part 2: Telling the Back from the Front or What the Chordates Invented (27:47)

submitted by: video_collector

In Part 2: Telling the back from the front or what the chordates invented, Marc Kirschner (Harvard Medical School) discusses why we look like invertebrate animals turned upside down, i.e. vertebrates have their central nervous system on their backs and invertebrates have it on their bellies.

Role of the Neural Crest in Vertebrate Development and Evolution: Part 3: The Molecular Control of the Neural Crest Contribution to Craniofacial and Brain Development (36:10)

submitted by: video_collector
Further studies have shown that the NC cells which participate in facial skeletogenesis correspond to the anteriormost region of the body axis where the genes of the Hox cluster are not expressed. If the forced expression of Hoxa2, Hoxa3 and Hoxb4 (the most anteriorly expressed Hox genes) is induced in this part of the neural fold, brain development is deeply affected with anencephaly and no skeletogenesis takes place in the face which fails to develop. This phenotype is reproduced when the...

Genomic association study (CHIP-Seq) of Liver X receptors beta in combination with gene expression analysis

submitted by: dougramsey

Genomic association study (CHIP-Seq) of Liver X receptors beta in combination with gene expression analysis presented by Lana Garmire, Bioengineering, UC San Diego

Reconstruction of Alternative Splice Variants and Associated Abundances from Short Sequence Reads (CSHL Genome Informatics Conference 2008)

submitted by: micha
The FLUX CAPACITOR : next generation sequencing technologies provide an unprecedented capacity for surveying the nucleic acid content of cells. This profound sequencing depth may allow in particular for exhaustively sequencing through the large dyanimc range of RNA abundances in the cell, overcoming limitations imposed by current (random) clone selection approaches. However, the very short reads produced by the most cost-effective such technologies make the reconstruction of complete RNA...

Epigenomics of Cancer - Prof. Wei Li (Part 1, 2009)

submitted by: ralanharris

Prof. Wei Li lectures on studies of transcription factor binding sites and histone modifications using ChIP-chip and Chip-seq assays. Part of the Computer Aided Discovery Methods 2009 course offered at Baylor College of Medicine.