Polymorphisms in genes involved in folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia

submitted by: LUCIANA TOMITA
High folate intake has been suggested as an important factor for cancer prevention; however, previous studies on the relationship between folate intake, serum folate and plasma homocysteine are controversial. We conducted a hospital-based, case-control study in Brazil investigating associations between dietary and circulating vitamins B-6, B-12 and folate, homocysteine, genotypes of folate-metabolizing enzyme methylenetetrahydrofolate reductase [MTHFR C677T, A1298C],...
Authors: Luciana Tomita, Vania d'Almeida, Luisa Villa, Eduardo Franco, Marly Cardoso

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women

submitted by: enphpdom
Background: Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were exposed to famine or who conceived in the Gambian rainy season. Objective: The objective was to understand the seasonality of DNA methylation patterns in rural Gambian women. We studied natural...
Authors: P Dominguez-Salas, AM Prentice

Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine

submitted by: Michelle Murphy
ABSTRACT Background: Folate, choline, and betaine participate in homocysteine metabolism. It is not known whether they interact during pregnancy. Objective: The objective was to investigate how folate status affects choline, betaine, and dimethylglycine during pregnancy. Design: Fasting plasma folate, cobalamin, free choline, betaine, dimethylglycine, and total homocysteine (tHcy) were measured longitudinally at ,12, 15, 24–27, and 34 gestational weeks (GW); at labor (nonfasting);...
Authors: Silvia Fernandez-Roig, Michelle M Murphy

Vision Changes after Spaceflight Are Related to Alterations in Folate– and Vitamin B-12–Dependent One-Carbon Metabolism

submitted by: szwart
Approximately 20% (7 of 38) of astronauts on International Space Station (ISS) missions have developed measurable ophthalmic changes after flight. This study was conducted to determine if the folate– and vitamin B-12?dependent 1-carbon metabolic pathway is altered in these individuals. Since 2006, we have conducted experiments on the ISS to evaluate nutritional status and related biochemical indices of astronauts before, during, and after flight. Data were modeled to evaluate differences...
Authors: Sara R. Zwart, C. Robert Gibson, Thomas H. Mader, Karen Ericson, Robert Ploutz-Snyder, Martina Heer, Scott M. Smith

Poor folate status predicts persistent diarrhea in 6- to 30.month old north Indian children

submitted by: mariskarmanger
Poor micronutrient status is associated with diarrheal illness, but it is not known whether low folate and/or cobalamin status are independent risk factors for diarrhea. We measured the association between plasma folate and cobalamin and subsequent diarrheal morbidity in a prospective cohort study of 2296 children aged 6–30 mo in New Delhi, India. Plasma concentrations of folate, cobalamin, total homocysteine (tHcy), and methylmalonic acid were determined at baseline. Whether a child had...
Authors: Mari s Manger