Clathrin-mediated endocytosis regulates occludin, and not focal adhesion, distribution during epithelial wound healing

submitted by: RappoportLab
BACKGROUND INFORMATION: Vesicle trafficking has long been suggested to play mechanistic roles in regulating directed cell migration. Recent evidence demonstrates that specific cell types and modes of migration involve transport of particular cargo through particular pathways. Epithelial wound healing is essential in tissue repair. However, investigations into the mechanisms regulating cell migration have mainly focused upon other models such as fibroblast-derived cells. Roles for vesicle...
Authors: Sarah Fletcher, Natalie Poulter, Elizabeth Haining, Joshua Rappoport

Adhesion, Signaling and Cancer: Part 3: Focal Adhesions as Stress Sensors (30:57)

submitted by: scivee-team
In the third segment of my seminar, I address a new frontier in cell biology, that is how cells respond to mechanical information. Cells and tissues are exposed to physical forces in vivo and excessive mechanical stress leads to a variety of pathological consequences. I describe a system for exposing cells to controlled mechanical stress and discuss the stretch response. We have discovered that the focal adhesion protein, zyxin, is exquisitely sensitive to mechanical stimulation and is...

Adhesion, Signaling and Cancer by Mary C. Beckerle, July 2007 - Part 1: Understanding Cancer From Its Beginnings (36:04)

submitted by: video_collector
Cell-substratum adhesion is mediated by integrins, a family of transmembrane, heterodimeric, extracellular matrix receptors that are concentrated at focal adhesions. Integin engagement influences a variety of signaling pathways and regulates cell behaviors including motility, proliferation, and survival. Disturbance of normal integrin function is associated with a variety of pathologic conditions including cancer. In the first segment of my seminar, I provide a broad overview of the cancer...