Background: Fatty acids in blood may be related to the risk of prostate cancer, but epidemiologic evidence is inconsistent. Blood fatty acids are correlated through shared food sources and common endogenous desaturation and elongation pathways. Studies of individual fatty acids cannot take this into account, but pattern analysis can. Treelet transform (TT) is a novel method that uses data correlation structures to derive sparse factors that explain variation. Objective: The objective...

Retinopathy is a common cause of blindness in all age groups. There are 15 million people in the United States with age-related macular degeneration (AMD)—20% of those aged 65 to 74 years and 30% aged
74 years—and 1.6 million of those have neovascular (wet) AMD. In the working age population there are
20 million (
7% of the population) with diabetes, and 50% of patients with diabetes mellitus have diabetic retinopathy (DR) after 25 years. In children, retinopathy of prematurity (ROP)...