Actin puts the squeeze on Weibel-Palade bodies

submitted by: JCB
The actin cytoskeleton has been proposed to regulate exocytosis in many different ways. Nightingale et al. use a two-color, live-cell imaging assay to reveal two contrasting functions of actin in distinct stages of Weibel-Palade body secretion: actin-based anchors inhibit the fusion of these secretory granules with the plasma membrane but, post-fusion, a contractile actin ring squeezes granule content out of the cell. This biosights episode presents the paper by Nightingale et al. from the...

Synaptic Land - The Movie

submitted by: KidsJudgePartnership
The story of how two behavioral neuroscience graduate students from Oregon Health & Science University conceived and constructed the very first "Synaptic Land", a game that helps kids learn about processes involved in neurotransmission. Since its debut at the Oregon Kids Judge! Neuroscience Fair held at OMSI in 2002, undergraduate and graduate students at many other universities have created their own versions of the Synaptic Land game (e.g., PENN, University of Scranton, California...