Apicomplexan Parasites, Pathogen Genome Informatics, and the Evolution of Eukaryotic Organelles: Part 3C: Designing and mining pathogen genome databases: From genes to drugs and vaccines (25:45)

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With the emergence of genomic-scale datasets representing all of the genes in the genome, all of the proteins in a cell or tissue, and all of the interactions and signals in an organism, biologists are increasingly faced with the challenge of how to store, integrate, and interrogate this information. How can we effectively mine large-scale datasets to expedite biological discovery, for example in the identification of new targets for anti-parasitic drug and vaccine design? Computational...

Apicomplexan Parasites, Pathogen Genome Informatics, and the Evolution of Eukaryotic Organelles: Part 3B: Designing and mining pathogen genome databases: From genes to drugs and vaccines (27:10)

submitted by: video_collector
With the emergence of genomic-scale datasets representing all of the genes in the genome, all of the proteins in a cell or tissue, and all of the interactions and signals in an organism, biologists are increasingly faced with the challenge of how to store, integrate, and interrogate this information. How can we effectively mine large-scale datasets to expedite biological discovery, for example in the identification of new targets for anti-parasitic drug and vaccine design? Computational...

Apicomplexan Parasites, Pathogen Genome Informatics, and the Evolution of Eukaryotic Organelles: Part 2: The apicomplexan plastid: Something old, something new, something borrowed, something green (37:11)

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Antibiotics are effective because they kill bacteria without harming humans and other eukaryotes (organisms with cells that contain nuclei). So why are the eukaryotic parasites responsible for malaria and toxoplasmosis killed by drugs like clindamycin? Multidisciplinary studies integrating molecular genetics, cell biology, biochemistry, pharmacology and computational genomics reveal that such drugs target an unusual organelle. The "apicoplast" was acquired when an ancestral organism 'ate' a...

Apicomplexan Parasites, Pathogen Genome Informatics, and the Evolution of Eukaryotic Organelles by David S. Roos, May 2008 - Part 1: How to build a parasite

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There are more than 5000 species of single-celled eukaryotes in the biological phylum known as the Apicomplexa, including the parasites responsible for malaria, neurological birth defects, and opportunistic infections associated with HIV/AIDS. These ancient protozoa provide a unique window into the evolution of subcellular organelles that have long fascinated cell biologists. Familiar features help to elucidate the origins, functions and design parameters for the secretory pathway,...