Epizyme - HMT "Tree" Presentation Video

submitted by: Epizyme
A survey of the human genome was performed to understand the constituency of protein methyltransferases (both protein arginine and lysine methyltransferases) and the relatedness of their catalytic domains. We identified 51 protein lysine methyltransferase proteins based on similarity to the canonical Drosophila Su(var)3-9, enhancer of zeste (E(z)), and trithorax (trx) domain. Disruptor of telomeric silencing-1-like, a known protein lysine methyltransferase, did not fit within the protein...
Authors: Christopher Sneeringer, Margaret Scott, Keith Elliston, Danielle Johnston, Lei Jin, L. fred Jerva, Victoria Richon, Robert Copeland, Christina Majer