T-Cell Epitope Prediction: Rescaling Can Mask Biological Variation between MHC Molecules

submitted by: aidanmcn
Theoretical methods for predicting CD8+ T-cell epitopes are an important tool in vaccine design and for enhancing our understanding of the cellular immune system. The most popular methods currently available produce binding affinity predictions across a range of MHC molecules. In comparing results between these MHC molecules, it is common practice to apply a normalization procedure known as rescaling, to correct for possible discrepancies between the allelic predictors. Using two of the most...
Authors: Aidan MacNamara, Ulrich Kadolsky, Charles R. M. Bangham, Becca Asquith