Vinculin minds the endothelial gap

submitted by: JCB
The adhesions between endothelial cells transiently remodel in response to angiogenic growth factors and inflammatory cytokines. Huveneers et al. reveal that remodeling takes place at a subset of adhesions called focal adherens junctions, which recruit the mechanosensory protein Vinculin to resist tension from the actomyosin cytoskeleton and avoid excessive disruption during the remodeling process. This biosights episode presents the paper by Huveneers et al. from the March 5, 2012, issue of...

T Cells Rho across the endothelium

submitted by: JCB
During an immune response, T cells move into tissues from the vasculature by crossing the endothelial cell layer lining blood vessel walls. Heasman et al. reveal that this transendothelial migration requires signaling at both the front and back of leukocytes by the small GTPase RhoA. This biosights episode presents the paper by Heasman et al. from the August 23, 2010 issue of The Journal of Cell Biology, and includes an interview with senior author Anne Ridley. Produced by Caitlin Sedwick...