From Tissue Slide To First Molecular Analysis within 24 hours. Fact or Fiction?

submitted by: LUMC_PA_MD
For a number of cancersubtypes it is crucial to determine if a mutation is present in genes like KRAS, EGFR, BRAF and PIK3CA. The testresults will be consequently used to predict the response to therapy. We demonstrate the workflow of this process in the Molecular Tumour Diagnostics group in the department of Pathology at the Leiden University Medical Center in the Netherlands. For more information: LUMC Pathology SLMP.nl (Dutch only) Citation: Rapid KRAS, EGFR, BRAF and PIK3CA...

DFG motif: A Protonation Dependent Conformational Switch

submitted by: icamvid

Yibing Shan gives a talk at the RPP08 conference about the mechanism of DFG flip in Abl kinase:
1) Simulation of DFG flip
2) An energetic model: the role of protonation
3) Experimental test
4) What's the DFG flip for?

Structural insights into EGF Receptor activation

submitted by: icamvid

Diego Alvarado gives a talk at the RPP08 conference on:
1) the structure of the EGF Receptor
2) An insight into the role of the auto-inhibitory tether from invertibrate EGFR homologs