CKIδ Decentralizes the Centrosome

submitted by: JCB
When a T cell encounters a target antigen-presenting cell, the lymphocyte's centrosome relocalizes to a specialized contact between the two cells called the immunological synapse. Zyss et al. reveal that casein kinase Iδ helps to reposition the centrosome in activated T cells, perhaps by working with the microtubule plus-end binding protein EB1 to regulate microtubule growth. This biosights episode presents the paper by Zyss et al. from the November 28, 2011, issue of The Journal of Cell...

Laminin Adhesions Help Microtubules Reach Base

submitted by: JCB
Microtubules align along the apical-basal axis of epithelial cells with their plus ends pointing to the basal side. Hotta et al. reveal how signals from the extracellular matrix establish this arrangement by recruiting the microtubule-anchoring factors LL5s to the basal cell cortex. This biosights episode presents the paper by Hotta et al. from the May 31, 2010 issue of The Journal of Cell Biology, and includes an interview with senior author Yuko Mimori-Kiyosue. Produced by Caitlin...