Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates UV induced melanocyte homeostasis

submitted by: arup.indra
Keratinocytes contribute to melanocyte activity by influencing their microenvironment, in part, through secretion of paracrine factors. Here we discovered that p53 directly regulates Edn1 expression in epidermal keratinocytes and controls UV-induced melanocyte homeostasis. Selective ablation of EDN1 in murine epidermis (EDN1ep-/-) does not alter melanocyte homeostasis in newborn skin but decreases dermal melanocytes in adult skin. Results showed that keratinocytic EDN1 in a non-cell...
Authors: Daniel J. Coleman, Gitali Ganguli-Indra, Stephen Hyter, Arup Indra, Steven Ma, Gary F. Merrill, Masashi Yanagisawa

Can Quantum Mechanics Play a Role in DNA Damage Detection?, Fröhlich Condensation and Quantum Consciousness

submitted by: icamvid

Daniel Cox presents theory and experiment showing a possible explanation for DNA damage detection through quantum behavior of electrons.

27:11
Jeffrey Reimers explores the most important question in fundamental science for this century: What is the origin of intelligence and consciousness? He presents quantum mechanical explanations for the origin of intelligence.

Presented at the Exploratory Workshop on Nontrivial Quantum Effects, Anacapri, Italy, October 2010