Uffe Hellsten on the first frog genome, X. tropicalis

submitted by: JGI

DOE JGI's Uffe Hellsten, first author of the April 30, 2010 Science publication about the first amphibian genome to be sequenced, talks about the importance of the African clawed frog.

What Genomes Can Tell Us About the Past by Sydney Brenner - Part 2: (42:36)

submitted by: video_collector

In the second part of talk, I explore other clues that suggest that genomes are not at equilibrium. Some genes appear to be changing more slowly and these older "fossil" genes in modern day genomes may give us insight into the distant past. I also hope to convince you that many of the great mysteries in contemporary biology do not require big research labs but can be solved through "home genomics"- piecing together information through a computer, the internet, and an inquisitive mind.

The Origin of Vertebrates - Part 3: How Chordates Got Their Chord (19:09)

submitted by: video_collector

In Part 3: How chordates got their chord, Marc Kirschner (Harvard Medical School) discusses how the overall body plan of vertebrates, arose from the invertebrates based on knowledge of the commonalities in their developmental mechanisms. Here again, the acorn worm, offers the key comparison, being close enough to us to share some recognizable features, but far enough away to indicate the direction from whence we came.

The Origin of Vertebrates - Part 2: Telling the Back from the Front or What the Chordates Invented (27:47)

submitted by: video_collector

In Part 2: Telling the back from the front or what the chordates invented, Marc Kirschner (Harvard Medical School) discusses why we look like invertebrate animals turned upside down, i.e. vertebrates have their central nervous system on their backs and invertebrates have it on their bellies.

Role of the Neural Crest in Vertebrate Development and Evolution: Part 3: The Molecular Control of the Neural Crest Contribution to Craniofacial and Brain Development (36:10)

submitted by: video_collector
Further studies have shown that the NC cells which participate in facial skeletogenesis correspond to the anteriormost region of the body axis where the genes of the Hox cluster are not expressed. If the forced expression of Hoxa2, Hoxa3 and Hoxb4 (the most anteriorly expressed Hox genes) is induced in this part of the neural fold, brain development is deeply affected with anencephaly and no skeletogenesis takes place in the face which fails to develop. This phenotype is reproduced when the...

Role of the Neural Crest in Vertebrate Development and Evolution - Part 2: The Role of the Neural Crest in Head Development and in Vertebrate Evolution (30:04)

submitted by: video_collector
Nicole Le Douarin shares her research on the role of the neural crest in skeletal development. The Q/C (quail/chick) marker system revealed that apart from the peripheral nervous system (PNS), the melanocytes and some endocrine tissues, the NC plays a major role in the construction of the vertebrate head. The entire facial skeleton and part of the skull (frontal, squamosal, parietal bones) are of NC origin together with the connective tissues of the face and ventral part of the neck. The...

The Problem of Regeneration: Part 3: Molecular Basis of Regeneration: Planarians as a Model System (43:54)

submitted by: video_collector

In the third and last part of this lecture, I will introduce the model system we have developed to study animal regeneration, the planarian Schmidtea mediterranea. I will review its anatomy, and the biological attributes that make these animals extraordinarily well suited to dissect the molecular and cellular basis of regeneration. I will also discuss recent work from my laboratory aimed at identifying molecules associated with regenerative capacities.

The Problem of Regeneration: Part 2: Principles of Planarian Regeneration (32:49)

submitted by: video_collector

In this second part of the lecture, I will briefly review the rich history of planarian research, followed by a summary of the central principles of planarian regeneration that have been derived from this extensive, often fascinating body of experimental work.

Developmental Biology of a Simple Organism: Part 3: Stochasticity and Cell Fate (25:03)

submitted by: scivee-team

Part III presents research showing that B. subtilis uses a bet hedging strategy for coping with uncertainty.

Developmental Biology of a Simple Organism: Part 2: New Research on Multicellularity (18:13)

submitted by: scivee-team

Part II presents research on the capacity of B. subtilis cells to form architecturally complex communities.