Microtubules Keep Tumor Cells Breathing Easy

submitted by: JCB
The transcription factor HIF-1α is essential for a cell's response to low oxygen conditions. Carbonaro et al. demonstrate that production of HIF-1α protein is regulated by dynamic microtubules and that microtubule-targeting drugs shift HIF-1α mRNA into cytoplasmic P-bodies, where its translation is repressed by miRNAs. This biosights episode presents the paper by Carbonaro et al. from the January 10, 2011, issue of The Journal of Cell Biology, and includes an interview with authors Marisa...

CyclinB1-Cdk1 Makes Its Move

submitted by: JCB
Cells drastically alter their structure at the onset of mitosis. Gavet and Pines reveal that the mitotic kinase CyclinB1-Cdk1 triggers its own nuclear import in prophase to ensure reorganization of the nucleus and cytoplasm is synchronized. This biosights episode presents the paper by Gavet and Pines from the April 19, 2010 issue of The Journal of Cell Biology, and includes an interview with senior author Jonathon Pines. Produced by Justin Paul and Ben Short. See the full article online...

Biology of Plants

submitted by: scivee-team

An overview of the process of photosynthesis and the biology of plants - function, reproduction and life.