Carol Post gives a talk at the RPP08 conference on Src, a mechanism of conformational activation. She covers two topics regarding it Src:
1) Switched electrostatic network
2) long-range coupling of regulatory SH2/SH3 and catalytic domain
Phineus Markwick gives a talk at the RPP08 conference long time-scale MD simulations of protein dynamics. He discusses experiments using dipolar coupling to probe the protein dynamics. From these he shows how to build a simulation.