Expanded umbilical cord blood shortens perilous wait for transplant recovery

submitted by: mdanderson

A team led by MD Anderson researchers finds that growing cord blood stem cells on a bed of supportive cells in the lab results in faster establishment of a new blood supply in patients who receive blood stem cell transplants, reducing the time when patients lack white blood cells, platelets.

Tumour cords' growth in a vascular network

submitted by: sast
Evolutions of oxygen concentration and formation of hypoxic zones during tumour growth in the vascular network . This simulation was produced with an experimental modification to the model, where vessels are oxygen sources inside the simulation domain, cells do not switch to anaerobic metabolism in this simulation. For more information refer to http://code.google.com/p/cord/ .

ATP deficit in oxygen-limited tumour cord growth (FF++)

submitted by: sast
This is a simulation of tumour cord growth , where cells suffer from hypoxia (energy deficit shown with colour). The tumour grows along the blood vessel (coincides with x -axis). Red line shows the position of the tumour–host interface. This particular simulation was programmed in FreeFEM++ out of curiousity. The source code for simulation may be found at http://code.google.com/p/cord . This video reflects work in progress and may be different from the final results .

Tissue movement in bipopulation tumour cord growth

submitted by: sast

Simulation of tumour cord growth where conversion of the tumour to glycolytic (anaerobic) metabolism takes place under hypoxia. This video shows volume fraction of glycolytic cell population and velocity of tissue movement. Isolines show hypoxia limits for aerobic and anaerobic cell lines respectively. This video reflects work in progress and may be different from the final results.

ATP deficit in bipopulation tumour cord growth

submitted by: sast

Simulation of tumour cord growth where conversion of the tumour to glycolytic (anaerobic) metabolism takes place under hypoxia. This video shows evolution of the region where the aerobic cells suffer from hypoxia (ATP deficit) as well as the limit where the glycolytic cells start suffering too. This video reflects work in progress and may be different from the final results.