Utilization of alternative initiation sites for protein translation directed by non-AUG codons in mammalian mRNAs is observed with increasing frequency. Alternative initiation sites are utilized for the synthesis of important regulatory proteins that control distinct biological functions. It is, therefore, of high significance to define the parameters that allow accurate bioinformatic prediction of alternative translation initiation sites (aTIS). This...
Authors: Jill l Wegrzyn, Thomas m Drudge, Faramarz Valafar, Vivian Hook
Understanding the molecular mechanisms responsible for the regulation of the transcriptome present in eukaryotic cells is one of the most challenging tasks in the postgenomic era. In this regard, alternative splicing (AS) is a key phenomenon contributing to the production of different mature transcripts from the same primary RNA sequence. As a plethora of different transcript forms is available in databases, a first step to uncover the biology that drives AS is to identify the different...
Authors: Michael Sammeth, Sylvain Foissac, Roderic Guigó
Janet Thornton, Ph.D. Head of European Bioinformatics Institute (EBI)
Dr. Thornton is a leading expert in relating protein sequence to structure and function. She has worked extensively in knowledge-based approaches to sequence analysis. Dr. Thornton is a member of the Royal Society