Real-time Ray Tracing of Complex Molecular Scenes with BALLView and RTfact

submitted by: akdehof

This is two posters given together relating to molecular visualization.

The Evolution of Beta Amyloid Cleaving Enzyme (BACE1): an Alzheimer’s Disease Drug Target

submitted by: cdsouthan
Plaque formation in Alzheimer's Disease (AD) is seeded by excision products of Amyloid precursor protein (APP) generated by the combined activities of beta and gamma secretases. To reduce the production of these neurotoxic peptides the inhibition of beta-secretase (Beta-site APP Cleaving Enzyme, BACE1, Swiss-Prot P56817) is being intensively pursued as a possible therapy for AD and all drug candidates are screened for selectivity against the paralogue (BACE2, Swiss-Prot Q9Y5Z0) which...

New Methods from the Berkeley Phylogenomics Group

submitted by: ruchira

Here we present two new algorithms hosted within the PhyloFacts phylogenomic encyclopedias.

Systematic Analysis of Human 5’UTR Introns Reveals Their Importance in Expression

submitted by: cancenik

Here, we describe a genome-scale computational analysis of 5’UTR introns in humans.

Networks, Systems and Biocomplexity - What Networks Can and Cannot Tell Us

submitted by: WomenInBioinformatics
Tarynn Witten, Ph.D. Director of Research & Development, Center for the Study of Biological Complexity, Virginia Commonwealth University. For the bulk of the history of biology and biomedicine, reductionism was the principle mode of investigation. While Ecologists caught on to the idea of systems in the late 1800's, Systems Biology, as a discipline, has not really emerged until the past decade when "omic hierarchical" data became readily available in online databases and through various...

Bookcast - Structural Bioinformatics 2nd Edition Gu & Bourne (Eds.)

submitted by: Phil
Further details of the book can be found at and on Google Books .

The R403Q Myosin Mutation Implicated in Familial Hypertrophic Cardiomyopathy Causes Disorder at the Actomyosin Interface

submitted by: apryl
Background Mutations in virtually all of the proteins comprising the cardiac muscle sarcomere have been implicated in causing Familial Hypertrophic Cardiomyopathy (FHC). Mutations in the β-myosin heavy chain (MHC) remain among the most common causes of FHC, with the widely studied R403Q mutation resulting in an especially severe clinical prognosis. In vitro functional studies of cardiac myosin containing the R403Q mutation have revealed significant changes in enzymatic and...
Authors: Dorit Hanein, Larnele Hazelwood, Susan Lowey, HongJun Lui, Kathleen M. Trybus, Niels Volkmann

The Biology of Genomes (2008) with Michael Ashburner Interviewed by Orli Bahcall

Michael Ashburner (1942-) is Professor of Biology at the University of Cambridge and is the former Joint-Head of the European Bioinformatics Institute (EBI).He was educated at the Royal Grammar School, High Wycombe and the University of Cambridge, where he received his undergraduate degree (1964) and Ph.D. (1968), both in genetics. He then went to the California Institute of Technology as a postdoctoral fellow with Hershell Mitchell. In 1979, he returned to the Department of Genetics in...

Bioinformatic analyses of mammalian 5'-UTR sequence properties of mRNAs predicts alternative translation initiation sites

linked profile(s): jwegrzyn
submitted by: apryl
Background Utilization of alternative initiation sites for protein translation directed by non-AUG codons in mammalian mRNAs is observed with increasing frequency. Alternative initiation sites are utilized for the synthesis of important regulatory proteins that control distinct biological functions. It is, therefore, of high significance to define the parameters that allow accurate bioinformatic prediction of alternative translation initiation sites (aTIS). This...
Authors: Jill l Wegrzyn, Thomas m Drudge, Faramarz Valafar, Vivian Hook

A General Definition and Nomenclature for Alternative Splicing Events

submitted by: micha
Understanding the molecular mechanisms responsible for the regulation of the transcriptome present in eukaryotic cells is one of the most challenging tasks in the postgenomic era. In this regard, alternative splicing (AS) is a key phenomenon contributing to the production of different mature transcripts from the same primary RNA sequence. As a plethora of different transcript forms is available in databases, a first step to uncover the biology that drives AS is to identify the different...
Authors: Michael Sammeth, Sylvain Foissac, Roderic Guigó