Polyketide Biosynthesis: The Erythromycin Example - Part 3: Enzymology of Erythromycin Polyketide Biosynthesis (42:11)

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In the final part, the enzymology of the erythromycin polyketide synthase is discussed.

Polyketide Biosynthesis: The Erythromycin Example - Part 2: Impact of Genetics and Molecular Biology on Understanding and Engineering Erythromycin Biosynthesis (22:44)

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In the second part, the contributions of genetics and molecular biology on investigations into erythromycin biosynthesis are summarized. The impact of these fields on biosynthetic engineering is also explained.

Computational Protein Design Part 2: Designing Protein Libraries and an Example of Making a Better Fluorescent Protein (33:50)

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In this lecture, I discuss the challenges of designing new proteins that fold into a particular structure or perform a particular function. One method is to computationally design a protein based solely upon our knowledge of amino acids and protein folding, a hard task but one which has had recent successes. Another approach is to screen combinatorial libraries of proteins for a desired function. In particular, I will discuss how structure-based computational methods can allow for high...

Polyketide Biosynthesis: The Erythromycin Example - Part 1: Overview of Polyketides and Polyketide Biosynthesis (34:10)

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In the first part, an overview of polyketides and polyketide biosynthesis is presented. A rationale for investigating polyketide biosynthesis is also presented.

For further informaton see: http://www.ascb.org/ibioseminars/Khosla/Khosla1.cfm

Design and Testing of Protein Combinatorial Libraries - Part 1: Introduction to Protein Design by Computation (31:09)

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In this lecture, I discuss the challenges of designing new proteins that fold into a particular structure or perform a particular function. One method is to computationally design a protein based solely upon our knowledge of amino acids and protein folding, a hard task but one which has had recent successes. Another approach is to screen combinatorial libraries of proteins for a desired function. In particular, I will discuss how structure-based computational methods can allow for high...

Computation Enabling Bio-Science & Engineering

submitted by: SDSC

Professor Richard Waltz discusses "Computation Enabling Bio-Science & Engineering" at the Cyberinfrastructure Experiences for Graduate Students Spring Orientation Workshop in 2007. For more information see: http://www.sdsc.edu/us/training/index.html