Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies.

submitted by: wbgrant
Background: Low vitamin D status may increase mortality risk. OBJECTIVE: We used nonparametric ("highest compared with lowest" categories) and parametric (>2 categories) statistical models to evaluate associations of 25-hydroxyvitamin D [25(OH)D] serum concentrations and mortality in observational studies among general populations. DESIGN: We searched PubMed, EMBASE, Web of Science, and reference lists for relevant articles. We included studies that contained data on relative risks (RRs)...
Authors: Armin Zittermann, Simona Iodice, Stefan Pilz, William B. Grant, Vincenzo Bagnardi, Sara Gandini

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration

submitted by: KuoOffice
Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in the developed world and has a strong genetic predisposition. A locus at human chromosome 10q26 affects the risk of AMD, but the precise gene(s) have not been identified. We genotyped 581 AMD cases and 309 normal controls in a Caucasian cohort in Utah. We demonstrate that a single-nucleotide polymorphism, rs11200638, in the promoter region of HTRA1 is the most likely causal variant for AMD at 10q26...
Authors: Kang Zhang