Curbing the Killer Instinct

submitted by: JCB
Natural Killer (NK) cells distinguish target cells from surrounding healthy tissue by integrating signals from a variety of activating and inhibitory receptors. Abeyweera et al. reveal that signals from inhibitory receptors limit NK cell activity by remodeling contacts with potential targets and inducing NK cell retraction. This biosights episode presents the paper by Abeyweera et al. from the February 21st, 2011, issue of The Journal of Cell Biology, and includes an interview with senior...