biosights: August 6, 2012 - Redistribution aids the pore

submitted by: JCB
In animal cells, the nuclear lamina keeps nuclear pore complexes evenly distributed throughout the nuclear envelope. Steinberg et al. reveal that fungi, which lack nuclear laminae, prevent their nuclear pores from clustering by moving them around on cytoskeletal tracks, a process that also helps to organize fungal chromosomes and optimize nucleocytoplasmic transport. This biosights episode presents the paper by Steinberg et al. from the August 6, 2012, issue of The Journal of Cell Biology...

Invitation - Re-upload

submitted by: juliahos

A quick tour through the field of genomics, from simple to complex - an algal cell dividing, lyonization in a cat, and newborn genetic testing, among other topics. This is a re-upload.

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration

submitted by: KuoOffice
Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in the developed world and has a strong genetic predisposition. A locus at human chromosome 10q26 affects the risk of AMD, but the precise gene(s) have not been identified. We genotyped 581 AMD cases and 309 normal controls in a Caucasian cohort in Utah. We demonstrate that a single-nucleotide polymorphism, rs11200638, in the promoter region of HTRA1 is the most likely causal variant for AMD at 10q26...
Authors: Kang Zhang

Separating Duplicated Chromosomes in Preparation for Cell Division: Part 3: Moving the Chromosomes to the Spindle Poles: the Mechanisms of Anaphase A (41:27)

submitted by: scivee-team

The third lecture presents evidence, largely from McIntosh's lab, that shows how microtubule depolymerization can move chromosomes in vitro and explores the nature of some of the protein complexes that can couple chromosomes to microtubules and take advantage of this reaction.

The Biology of Genomes (2008) with Michael Ashburner Interviewed by Orli Bahcall

Michael Ashburner (1942-) is Professor of Biology at the University of Cambridge and is the former Joint-Head of the European Bioinformatics Institute (EBI).He was educated at the Royal Grammar School, High Wycombe and the University of Cambridge, where he received his undergraduate degree (1964) and Ph.D. (1968), both in genetics. He then went to the California Institute of Technology as a postdoctoral fellow with Hershell Mitchell. In 1979, he returned to the Department of Genetics in...

When it Comes to the Rat Genome, Bigger is Better

submitted by: dabraham
The rat genome comes to life through the use of the Gviewer tool. This video will show you how to use this helpful tool within the RGD website at http://rgd.mcw.edu/ . Genes, QTLs, and species syntenies of interest can all be visualized with ease as the Gviewer zooms in and navigates through the rat genome with a few clicks. See our website at http://rgd.mcw.edu/ for more tools for rat researchers.