Adhesion, Signaling and Cancer: Part 2: Discovery and Characterization of a Focal Adhesion Protein Implicated in Tumor Progression (50:54)

submitted by: scivee-team

In the second segment, I describe the identification of the focal adhesion protein, zyxin, by my lab. Recent work revealed that zyxin is down-regulated upon expression of the Ewing sarcoma oncoprotein, EWS-FLI. Loss of zyxin expression results in enhanced cell motility and is also associated with failed apoptotic signaling. Evidence that zyxin shuttles between focal adhesions and the nucleus is presented. The impact of reduced zyxin expression on tumor progression is discussed.

Foundations for Bayesian Updating

submitted by: dougramsey
We provide a simple characterization of updating rules that can be rationalized as Bayesian. Namely, we consider a general setting in which an agent observes finite sequences of signals and reports probabilistic predictions on the underlying state of the world. We study when such predictions are consistent with Bayesian updating, i.e., when does there exist some theory about the signal generation process that would be consistent with the agent behaving as a Bayesian updater. We show that the...