Cell Organization & Cell Motility: Part 3: Principles of Cellular Organization: The Universal Cytoskeleton (29:17)

submitted by: scivee-team
In the third part, I discuss how the complex shapes of cells are created by the cytoskeleton, and I compare and contrast prokaryotes (which have actin-, tubulin-, and intermediate filament -like proteins) and eukaryotes in this regard. In particular, I speculate that cytoskeletal dynamics were necessary to evolve simple bacterial shapes and cell division, but that additional layers of complexity (namely regulated nucleation and molecular motors) allowed eukaryotes to evolve more complex...

The PDZ Domain as a Complex Adaptive System

submitted by: akourakine
Specific protein associations define the wiring of protein interaction networks and thus control the organization and functioning of the cell as a whole. Peptide recognition by PDZ and other protein interaction domains represents one of the best-studied classes of specific protein associations. However, a mechanistic understanding of the relationship between selectivity and promiscuity commonly observed in the interactions mediated by peptide recognition modules as well as its functional...
Authors: Alexei Kurakin, Andrzej Swistowski, Susan c. Wu, Dale e. Bredesen