Tying the Golgi Ribbon to the Centrosome

submitted by: JCB
The mammalian Golgi apparatus exists as a continuous ribbon that clusters around the centrosome, but the significance of this organization is unclear. Hurtado et al. identify truncation mutants of the protein AKAP450 that differentially affect Golgi integrity and positioning, and use these mutants to investigate how the Golgi's organization contributes to its function in cell polarization, migration, and ciliogenesis. This biosights episode presents the paper by Hurtado et al. from the May...

Pulling centrosomes to the forward position

submitted by: JCB
Most migrating cells place their centrosome in front of the nucleus, facing the direction in which the cell is moving. Manneville et al. identify a signaling pathway that moves the centrosome into position by recruiting the motor protein dynein to leading edge microtubules. This biosights episode presents the paper by Manneville et al. from the November 1, 2010 issue of The Journal of Cell Biology, and includes an interview with senior author Sandrine Etienne-Manneville (Institut Pasteur,...