Wnt/beta-catenin signaling is stimulated by alpha-Melanocyte-Stimulating Hormone in melanoma and melanocyte cells: implication in cell differentiation.

submitted by: bbellei
Wnt/?-catenin signaling plays important roles in many developmental processes including neural crest-derived melanocyte development and migration. However, the effective contribution of Wnt/?-catenin pathway in melanogenesis in adult human melanocytes has not been fully elucidated. Here, we report that in melanoma cells and in normal human melanocytes melanogenesis stimulation by ?-MSH induces phosphorylation of ?-catenin-Ser675 and stabilization of ?-catenin protein. Activation of PKA by...
Authors: Barbara Bellei