Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge

submitted by: JCB
Chemoattractant signaling induces the polarization and directed movement of cells secondary to the activation of multiple effector pathways. In addition, chemotactic signals can be amplified and relayed to proximal cells via the synthesis and secretion of additional chemoattractant. The mechanisms underlying such remarkable features remain ill defined. We show that the asymmetrical distribution of adenylyl cyclase (ACA) at the back of Dictyostelium discoideum cells, an essential determinant...
Authors: Paul Kriebel, Valarie Barr, Erin Rericha, Guofeng Zhang, Carole Parent