Zinc supplementation improves bone density in patients with thalassemia: a double-blind, randomized, placebo-controlled trial

submitted by: efung
BACKGROUND: Patients with thalassemia major (Thal) frequently have low plasma zinc, which has been associated with low bone mass. OBJECTIVE: The objective was to determine the effect of zinc supplementation on bone mass in patients with Thal. DESIGN: Forty-two subjects (21 females aged 10-30 y) with Thal and low bone mass were randomly assigned to receive 25 mg Zn/d or placebo. Bone mineral content (BMC) and areal bone mineral density (aBMD) were assessed by using dual-energy X-ray...
Authors: Ellen B. Fung, Janet L. Kwiatkowski, James N. Huang, Ginny Gildengorin, Janet C. King, Elliott P. Vichinsky

Retinol May Counteract the Negative Effect of Cadmium on Bone

submitted by: agnake
Cadmium and high vitamin A intake are both proposed risk factors for low bone mineral density (BMD), but potential interactions have not been studied. Within the Women’s Health in the Lund Area, a population-based study in southern Sweden,wemeasured retinol in serumamong 606womenaged 54–64 y. Data onBMDwere measured byDXAat the distal forearm. Parathyroid hormone (PTH), bone alkaline phosphatase (bALP), and osteocalcin in serum and deoxypyridinoline (DPD) and cadmium in urine were...
Authors: Thomas Lundh, Jonas Lidfeldt, Per Bjellerup, Staffan Skerfving, Helen Håkansson, Annette Engström, Göran Samsioe, Marie Vahter, Agneta Åkesson

Dietary Intake of Arachidonic Acid and alpha-Linolenic Acid are Associated with Reduced Risk of Hip Fracture in Older Adults

submitted by: emily.farina
PUFA are hypothesized to influence bone health, but longitudinal studies on hip fracture risk are lacking. We examined associations between intakes of PUFA and fish, and hip fracture risk among older adults (n = 904) in the Framingham Osteoporosis Study. Participants (mean age ~75 y at baseline) were followed for incident hip fracture from the time they completed the baseline exam (1988-1989) until December 31, 2005. HR and 95% CI were estimated for energy-adjusted dietary fatty acid...
Authors: Ek Farina, Dp Kiel, R Roubenoff, Ej Schaefer, La Cupples, Kl Tucker

Dietary protein and bone health: a systematic review and meta-analysis.

submitted by: adarling
BACKGROUND: There has been a resurgence of interest in the controversial relation between dietary protein and bone health. OBJECTIVE: This article reports on the first systematic review and meta-analysis of the relation between protein and bone health in healthy human adults. DESIGN: The MEDLINE (January 1966 to September 2007) and EMBASE (1974 to July 2008) databases were electronically searched for all relevant studies of healthy adults; studies of calcium excretion or calcium balance were...
Authors: Al Darling, Dj Millward, Dt Torgerson, Ce Hewitt, Sa Lanham-new