Leukemia (AML/MDS) Moon Shots update

submitted by: mdanderson
Download from iTunes: https://itunes.apple.com/us/podcast/leukemia-aml-mds-moon-shots/id431848... . Acute Myeloid leukemia (AML) involves an overgrowth of immature blood cells, while myelodysplastic syndromes (MDS) happen when the bone marrow does not produce enough blood cells. MD Anderson Cancer Center is the world’s largest practice for treating AML and MDS. Guillermo Garcia-Manero, M.D., professor in Leukemia at MD Anderson, discusses milestones made with this MD Anderson moon shots,...

Unrelated Donor Bone Marrow Transplant for Sickle Cell Disease

submitted by: mcgheek
Jennifer Jaroscak, M.D., of MUSC Children's Hospital discusses bone marrow transplant (BMT) as a cure for patients with sickle cell disease. She describes a new reduced-intensity conditioning (RIC) regimen being trialed at MUSC for BMTs from well-matched unrelated donors in the SCURT study. RIC is safer for unrelated donor transplant because, unlike myeloablative BMTs, it suppresses but does not destroy the patient's bone marrow. Find out more about the SCURT study and reduced-intensity...

Facts about myelodysplastic syndrome

submitted by: mdanderson
Around 15,000 people in the United States are diagnosed each year with myelodysplastic syndrome (MDS). MDS occurs when the bone marrow does not properly produce one or more of the following: red blood cells, white blood cells and/or platelets. In the past it was thought MDS was only deadly when it developed into acute myelogenous leukemia (AML), but current research shows MDS can be fatal without reaching the stage of AML. Guillermo Garcia-Manero, M.D., professor in Leukemia, explains the...

Acute myeloid leukemia (AML) - a life threatening cancer

submitted by: mdanderson

Acute myeloid leukemia (AML) occurs when too many immature blood cells are produced by the bone marrow. Anemia, infection and bleeding may result and become life threatening. Guillermo Garcia-Manero, M.D., professor in Leukemia at MD Anderson Cancer Center, explains the symptoms, diagnosis and treatment of Acute myeloid leukemia.

Childhood Leukemia: Most Common Childhood Cancer

submitted by: mdanderson

Childhood leukemia is the most common childhood cancer with more than 3,500 children in the U.S. diagnosed each year. Patrick Zweidler-McKay, M.D., Ph.D., Assistant Professor at The University of Texas MD Anderson Cancer Center Children’s Cancer Hospital, talks about symptoms, diagnoses and treatment of this blood disease. Zweidler-McKay also discusses health problems that may occur decades after treatment and encourages long term follow-up doctor visits.

The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase

submitted by: tracyanthony
Amino acid starvation by asparaginase (ASNase) enhances phosphorylation of eIF2 by general control nonderepressible 2 (GCN2) kinase, leading to reduced global mRNA translation rates. This conserves energy and allows cells time to reprogram stress-related gene expression to alleviate cell injury. This study addressed the importance of GCN2 for the immune system to adapt to amino acid starvation by ASNase. GCN2+/+ and GCN2-/- mice were injected once daily with ASNase or saline for up to 7 d....
Authors: Carla Aldrich, Ronald Wek, Rachel Reinert, Judy Cundiff, Piyawan Bunpo, Tracy Anthony

Therapies for Multiple Sclerosis

submitted by: alex01

J. Kocsis, PhD. - The current approaches to the therapy of multiple sclerosis are reviewed by J. Kocsis (Yale University). His research emphasizes remyelination as an approach to the therapy of multiple sclerosis and spinal cord injury.