Zinc supplementation improves bone density in patients with thalassemia: a double-blind, randomized, placebo-controlled trial

submitted by: efung
BACKGROUND: Patients with thalassemia major (Thal) frequently have low plasma zinc, which has been associated with low bone mass. OBJECTIVE: The objective was to determine the effect of zinc supplementation on bone mass in patients with Thal. DESIGN: Forty-two subjects (21 females aged 10-30 y) with Thal and low bone mass were randomly assigned to receive 25 mg Zn/d or placebo. Bone mineral content (BMC) and areal bone mineral density (aBMD) were assessed by using dual-energy X-ray...
Authors: Ellen B. Fung, Janet L. Kwiatkowski, James N. Huang, Ginny Gildengorin, Janet C. King, Elliott P. Vichinsky

Retinol May Counteract the Negative Effect of Cadmium on Bone

submitted by: agnake
Cadmium and high vitamin A intake are both proposed risk factors for low bone mineral density (BMD), but potential interactions have not been studied. Within the Women’s Health in the Lund Area, a population-based study in southern Sweden,wemeasured retinol in serumamong 606womenaged 54–64 y. Data onBMDwere measured byDXAat the distal forearm. Parathyroid hormone (PTH), bone alkaline phosphatase (bALP), and osteocalcin in serum and deoxypyridinoline (DPD) and cadmium in urine were...
Authors: Thomas Lundh, Jonas Lidfeldt, Per Bjellerup, Staffan Skerfving, Helen Håkansson, Annette Engström, Göran Samsioe, Marie Vahter, Agneta Åkesson